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Fibromyalgia & Chronic Widespread Pain Research Reagents

abinScience provides high-quality recombinant neurotrophins (BDNF, NGF), pro-inflammatory cytokines, glial activation markers and in vivo-grade blocking antibodies for fibromyalgia and chronic widespread pain research, focusing on central sensitization, glial activation and neuro-immune interactions (acid-saline, reserpine, chronic stress models). Every lot released with detailed CoA. For research use only (RUO).

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Selection guide

  1. Neurotrophins: Elevated BDNF/NGF in CSF of fibromyalgia patients → use in vivo-grade anti-NGF or anti-TrkA for pain reversal studies.
  2. Neuroinflammation: Spinal microglia (Iba1) and astrocyte (GFAP) activation; cytokines (IL-6, IL-8) in plasma/CSF.
  3. Central sensitization: Phospho-NR1 and pERK in dorsal horn as mechanistic readouts.
  4. Models: Repeated acid-saline IM injection, reserpine-induced, chronic stress — all show widespread mechanical allodynia.
  5. Biomarkers: S100B and cytokine panels in patient serum; translate with validated ELISA.

Spotlight

 

Anti-NGF (mAb) — In Vivo Grade

Endotoxin <0.01 EU/µg • Reversal of widespread pain in models

 

Anti-GFAP — Astrocyte Marker

Robust staining in fibromyalgia-like models

 

IL-6 / IL-8 Duplex ELISA Kit (RUO)

pg/mL sensitivity • Plasma & CSF validated

FAQs

Why is anti-NGF promising for fibromyalgia?

NGF is dramatically elevated in patient CSF; anti-NGF antibodies (e.g., tanezumab phase studies) reverse widespread pain in preclinical models and showed efficacy in clinical trials.

Glial activation in fibromyalgia?

Spinal microglia and astrocytes drive central sensitization via cytokine release; Iba1/GFAP upregulation is a hallmark of fibromyalgia-like pain states.

Are these products for clinical use?

All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic procedures.

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