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Epilepsy Research Reagents

abinScience offers high-quality recombinant potassium channels (KCNQ2/3), SV2A, GABA-A receptor subunits, validated antibodies and RUO assay kits for epilepsy research, supporting studies on neuronal hyperexcitability, synaptic vesicle release and neuroinflammation in models such as kainate, pilocarpine, PTZ and kindling. Every lot released with detailed CoA. For research use only (RUO).

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Selection guide

  1. Ion channel targets: KCNQ2/3 for M-current enhancement (retigabine/ezogabine mechanism).
  2. Synaptic vesicle target: SV2A for levetiracetam/brivaracetam binding studies.
  3. Inhibitory tone: GABA-A α1, α2, γ2 subunits for benzodiazepine and neurosteroid action.
  4. Neuroinflammation: HMGB1/TLR4 pathway in acquired epilepsy.
  5. Models: Chemical (PTZ, kainate, pilocarpine) vs electrical kindling — choose reagents accordingly.

Spotlight

 

KCNQ2/3 Heterotetramer, Recombinant

Functional M-current • Retigabine activator validated

 

Anti-SV2A (mAb) — Levetiracetam Target

IHC & WB • Low background

 

Anti-GABA-A α1 (mAb)

Benzodiazepine site marker • Epilepsy models validated

FAQs

Why focus on KCNQ2/3 in epilepsy?

KCNQ2/3 form the M-current; loss-of-function mutations cause neonatal epilepsy, and openers (retigabine, ezogabine) suppress seizures.

SV2A antibodies for levetiracetam research?

SV2A is the direct binding target of levetiracetam and brivaracetam; our antibodies are validated for IHC in epilepsy models.

Are these products for clinical use?

All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic procedures.

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