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Bipolar Disorder Research Reagents

abinScience provides high-quality recombinant proteins (CLOCK, GSK3β, BDNF), validated phospho-specific antibodies and RUO ELISA kits for bipolar disorder research, focusing on circadian rhythm disruption, mood stabilizer targets (lithium, valproate), neurotrophic and mitochondrial pathways. Every lot includes detailed CoA. For research use only (RUO).

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Selection guide

  1. Circadian hypothesis: CLOCK/BMAL1 antibodies for rhythm disruption and sleep-phase studies.
  2. Mood stabilizer targets: GSK3β (pS9 inactive form for lithium response), IMPase/inositol monophosphatase.
  3. Neuroplasticity: BDNF/TrkB pathway for antidepressant and mood-stabilizing effects.
  4. Dopaminergic system: D1/D2 receptor antibodies for mania models.
  5. Animal models: CLOCK mutants, lithium/valproate chronic treatment, amphetamine-induced mania.

Spotlight

 

Anti-GSK3β pS9 (mAb) — Lithium Marker

Detects lithium/valproate-induced inactivation • WB/IHC validated

 

CLOCK Recombinant Protein

Full-length • Interaction with BMAL1 validated

 

BDNF ELISA Kit (RUO)

pg/mL sensitivity • Serum/plasma/brain lysate validated

FAQs

Why is GSK3β pS9 important in bipolar research?

Lithium and valproate inhibit GSK3β by increasing phosphorylation at Ser9; pS9 level is a direct pharmacodynamic marker of mood stabilizer treatment.

CLOCK/BMAL1 vs BDNF for mood disorder models?

CLOCK/BMAL1 disruption mimics mania-like behavior and circadian misalignment; BDNF/TrkB reduction is associated with depressive episodes and restored by mood stabilizers/antidepressants.

Can these products be used clinically?

All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic use.

8 product results for "Bipolar Disorder"

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