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Major Depressive Disorder Research Reagents

abinScience provides high-quality recombinant neurotrophins (BDNF pro/mature), serotonin transporter (SERT), TrkB, glucocorticoid receptor proteins, validated antibodies and RUO ELISA kits for major depressive disorder and stress-related research (CUMS, learned helplessness, social defeat models). Every lot released with detailed CoA. For research use only (RUO).

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Selection guide

  1. Neurotrophic hypothesis: Use pro-BDNF vs mature BDNF antibodies to distinguish plasticity vs apoptosis pathways.
  2. Serotonergic system: SERT for transporter studies; 5-HT1A for autoreceptor vs postsynaptic signaling.
  3. HPA axis: Glucocorticoid receptor (NR3C1) and FKBP5 for stress response and corticosteroid sensitivity.
  4. Neuroinflammation: Iba1/TMEM119 for microglia activation in depression models.
  5. Behavioral models: Pair with FST/TST/SPT kits and validated positive controls (ketamine, fluoxetine).

Spotlight

 

Mature BDNF, Recombinant (HEK)

Bioactive dimer • Purity ≥98% • Validated TrkB phosphorylation

 

Anti-proBDNF (specific mAb)

No cross-reactivity with mature BDNF • IHC & WB validated

 

BDNF ELISA Kit (RUO)

pg/mL sensitivity • Matrix-validated • Full linearity data

FAQs

proBDNF vs mature BDNF — which one for depression studies?

proBDNF (via p75NTR) promotes apoptosis and LTP suppression; mature BDNF (via TrkB) drives neurogenesis and antidepressant effects. Use specific antibodies to distinguish.

Is serum BDNF a reliable biomarker?

Peripheral BDNF correlates with brain levels and antidepressant response in many studies, but matrix effects require validated kits.

Are these products cleared for clinical use?

All products are for Research Use Only (RUO) and not intended for diagnostic or therapeutic procedures.

28 product results for "Major Depressive Disorder"

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