| Catalog No. | HB016026 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | IL7R, Interleukin-7 receptor subunit alpha, IL-7R-alpha, IL-7 receptor subunit alpha, CD127, CDw127, IL-7R subunit alpha, IL-7RA |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P16871 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2622254-57-1 |
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| Background | HY-P990911 is an IL7R-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096).
• CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases., PMID:35015026
• IL-7-dependent and -independent lineages of IL-7R-dependent human T cells., PMID:39352394
• The IL-7R antagonist lusvertikimab reduces leukemic burden in xenograft ALL via antibody-dependent cellular phagocytosis., PMID:38518105
• APOE ε4-associated downregulation of the IL-7/IL-7R pathway in effector memory T cells: Implications for Alzheimer's disease., PMID:39129310
• Phenotypic signatures of immune selection in HIV-1 reservoir cells., PMID:36599977
• The Therapeutic Values of IL-7/IL-7R and the Recombinant Derivatives in Glioma: A Narrative Review., PMID:37566474
• IL-7R-mediated signaling in T-cell acute lymphoblastic leukemia: An update., PMID:30249539
• IL7R, GZMA and CD8A serve as potential molecular biomarkers for sepsis based on bioinformatics analysis., PMID:39654893
• Phase I Trial of GD2.CART Cells Augmented With Constitutive Interleukin-7 Receptor for Treatment of High-Grade Pediatric CNS Tumors., PMID:38771986
• Structural basis of γ chain family receptor sharing at the membrane level., PMID:37535730
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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