| Catalog No. | HF004056 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Chimeric |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | HER1, Receptor tyrosine-protein kinase erbB-1, Proto-oncogene c-ErbB-1, Epidermal growth factor receptor, EGFR, ERBB1, ERBB |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P00533 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | CetuxiMab-GEX, GEXMab52201, 1646321-00-7 |
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| Background | HY-P990957 is an EGFR-targeting IgG1κ type chimeric antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
• Recent advances in the development of EGFR degraders: PROTACs and LYTACs., PMID:35728507
• Epidermal growth factor receptor inhibitors as potential anticancer agents: An update of recent progress., PMID:34628226
• Targeting of ErbB1, ErbB2, and their Dual Targeting Using Small Molecules and Natural Peptides: Blocking EGFR Cell Signaling Pathways in Cancer: A Mini-Review., PMID:35549881
• Small Molecule EGFR Inhibitors as Anti-Cancer Agents: Discovery, Mechanisms of Action, and Opportunities., PMID:36768973
• Epidermal growth factor receptor activity upregulates lactate dehydrogenase A expression, lactate dehydrogenase activity, and lactate secretion in cultured IB3-1 cystic fibrosis lung epithelial cells., PMID:33481676
• Irreversible multitargeted ErbB family inhibitors for therapy of lung and breast cancer., PMID:25435079
• Profiling epidermal growth factor receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology., PMID:23700486
• Lapatinib in breast cancer - the predictive significance of HER1 (EGFR), HER2, PTEN and PIK3CA genes and lapatinib plasma level assessment., PMID:21293538
• Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer., PMID:26337388
• Selection of DNA aptamers against epidermal growth factor receptor with high affinity and specificity., PMID:25242523
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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