| Catalog No. | DS870038 |
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| Sample type | Plasma, Serum |
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| Sensitivity | 0.156 μg/ml |
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| Range | 0.31-5 μg/mL |
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| Accession | Q15116 |
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| Applications | ELISA |
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| Detection method | Colorimetric |
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| Assay type | Quantitative |
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| Recovery | 80-120% |
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| Shipping | 2-8 ℃ |
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| Stability and Storage | The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 20% prior to the expiration date under appropriate storage condition. |
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| Specifications | Nivolumab |
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| Alternate Names | BMS-936558, MDX-1106, ONO-4538, CAS: 946414-94-4 |
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| Background | Nivolumab is a human immunoglobulin G4 (IgG4) monoclonal antibody that binds to the programmed cell death 1 (PD-1) receptor and selectively blocks interaction with its programmed death ligands PD-L1 and PD-L2. Upregulation of PD-1 ligands occurs in some tumors and signalling through this pathway can contribute to inhibition of active T-cell immune surveillance of tumour tissue. The inhibitory effect of PD-1 and its ligands occurs through the promotion of apoptosis in antigen specific T cells while simultaneously blocking apoptosis in suppressor T cells. Blocking PD-1 activity has been shown to lead to decreased tumour growth in mouse tumour models. |
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| Note | For Research Use Only. |
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