All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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iga/IgA1 protease (1)

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shiga toxin type 2/stx2B (1)

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gp120 (2)

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shiga toxin type 1B/stx1B (2)

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S1 N-terminal domain/S1-NTD (3)

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F/Fusion glycoprotein F0 (16)

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wlaB/pglK (1)

ARG1/Arginase-1 (2)

gB (2)

CCL1/I-309 (1)

CXCL13/BCA-1/BLC (1)

CD295/LEPR (1)

ALPP/PLAP (1)

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botA/BOTOX (1)

RHDV VP60 (1)

CD268/TNFRSF13C (2)

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ANGPTL3 (1)

EDB & CD3E (1)

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CD279/PD-1 (9)

IL12B/IL-12 p40 (1)

SOD1 (1)

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long-chain neurotoxin (1)

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ADAMTS4 (4)

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SLC39A6/LIV-1 (1)

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CD254/RANKL/TNFSF11 (1)

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tetX/Tetanus toxin (1)

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GDF11/BMP11 (1)

Hemagglutinin/HA (1)

CD62L/SELL (1)

BAG3 (1)

RSPO3 (1)

Alpha-cobratoxin (1)

Outer capsid glycoprotein VP7 (1)

shiga toxin type 2A/stx2A (1)

CSF2/GM-CSF (1)

OPN/SPP1 (1)

IGF1 (1)

ProteinUL128 & UL131A (1)

Procapsid [(VP0/1/3) 5] 12 (2)

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NLRP3 (1)

gp140/Env Trimer (2)

CD226/DNAM-1 (1)

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A35R (5)

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CD84 (1)

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CD37/TSPAN26 (2)
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Human hepatitis A virus (HHAV) (1)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

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Puumala virus (PUUV) (2)

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Reston ebolavirus (REBOV) (1)

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Human herpesvirus 1 (HSV-1/HHV-1) (3)

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Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

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Human cytomegalovirus (HCMV/HHV-5) (7)

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Dog (10)

Machupo virus (MACV) (1)

Seoul virus (SEOV) (2)

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Tai Forest ebolavirus (TAFV) (1)

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Human papillomavirus 59 (HPV59) (1)

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Human (177)

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Porcine circovirus 2 (PCV2) (2)

Hantaan virus (HTNV) (2)

Cat (1)

Zaire ebolavirus (ZEBOV) (6)

Human parvovirus B19 (HPV B19) (3)

E. coli (4)

Human papillomavirus 6 (HPV6) (1)
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Neutralization (706)

in vivo neutrophil depletion (2)

in vivo study (1)

Cell Depletion (1)

Neutralizatio (1)

in vivo research (1)

in vivo MDSC depletion (2)

ELISA (621)

in vivo neutralization (5)

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in vivo protection (1)

neutralizing (1)

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in vivo CD8+ T cell depletion (1)

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in vivo intra-tumoral regulatory T cell depletion (2)

ICC (3)

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NK cell activation (1)

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IHC (18)

in vivo (2)

Blocking (2)

Antagonist (1)

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IP (9)

Nneutralization (1)

Cell Isolation (1)
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IgG1b12 (1)

RD114 retrovirus (1)

Nipah virus (NiV) (13)

E. coli (1)

Puumala virus (1)

O'nyong'nyong virus (ONNV) (1)

Dengue Virus type 4 (DENV-4) (1)

Influenza A virus (H7N9) (1)

Japanese encephalitis virus (JEV) (2)

HIV-1 (1)

Zika virus (1)

Bacteriophage H19B (2)

Clostridium perfringens (3)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Epstein-Barr virus (EBV/HHV-4) (3)

Crimean-Congo hemorrhagic fever virus (2)

Nipah virus (1)

Influenza B virus (2)

Human metapneumovirus (HMPV) (1)

MERS-CoV (2)

Semliki Forest virus (SFV) (1)

Yellow Fever Virus (YFV) (1)

Measles virus (MeV) (2)

Murine norovirus 1 (MNV) (1)

Sin Nombre Virus (1)

Monkeypox virus (MPXV) (12)

Mouse (25)

Bovine viral diarrhea virus (BVDV) (2)

Venezuelan equine encephalitis virus (VEEV) (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Escherichia coli (1)

Corynephage omega (3)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Zika virus (ZIKV) (1)

Vesicular stomatitis Indiana virus (VSIV) (2)

Chikungunya virus (1)

Human enterovirus 71 (EV71) (3)

Bacillus anthracis (2)

Western equine encephalitis virus (WEEV) (1)

Junin mammarenavirus (JUNV) (3)

Poliovirus type 1 (PV1) (1)

Influenza A virus (1)

Listeria monocytogenes (1)

Klebsiella pneumoniae (1)

Guertu Virus (GTV) (3)

West Nile virus (WNV) (1)

Norwalk virus (NV) (5)

Canine parvovirus (1)

Rabies virus (RABV) (6)

Machupo virus (MACV) (1)

Parainfluenza virus 5 (PIV5) (1)

Staphylococcus aureus (3)

Monkeypox virus (5)

Rat (5)

Streptococcus equisimilis (1)

Eastern equine encephalitis virus (EEEV) (1)

Ophiophagus hannah (1)

Scorpion (2)

Theileria parva (1)

Heartland Virus (HRTV) (1)

HAstV-1 (2)

Hepatitis E virus/HEV (3)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Homo sapiens (Human) (1)

HCoV-229E (2)

Pig (1)

O’nyong’nyong virus (ONNV) (1)

Tick-borne encephalitis virus (1)

Chikungunya virus (CHIKV) (4)

Dengue Virus type 1 (DENV-1) (1)

Human papillomavirus 16 (HPV16) (13)

Influenza A virus (H7N1) (1)

SARS-CoV (1)

Monkey (1)

Clostridium botulinum (1)

Clostridium tetani (1)

HCoV-OC43 (1)

Clostridioides difficile (2)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Human (57)

Coxsackievirus B1 (CVB1) (3)

Mexican scorpion (3)

Foot-and-mouth disease virus (FMDV) (2)

Porcine circovirus 2 (PCV2) (1)

Human cytomegalovirus (HCMV/HHV-5) (1)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Mayaro virus(MAYV) (1)

Human astrovirus-2 (1)

Human astrovirus-8 (HAtVs) (1)

Dengue Virus type 2 (DENV-2) (1)

Influenza A virus (H7N3) (2)

SARS-CoV-2 (1)

HSV-1 (3)

Hepatitis E virus (2)

Naja kaouthia (1)

HCoV-NL63 (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Hendra virus (HeV) (12)

Hepatitis C Virus (HCV) (43)

Influenza A virus H7 subtype (2)

Ross River Virus (RRV) (2)

Dengue Virus type 3 (DENV-3) (1)

Lassa virus (LASV) (16)

HSV-2 (3)

Norwalk virus (3)

Dengue virus (1)

Human respiratory syncytial virus (HRSV) (5)

Hendra virus (1)

Coxsackievirus A16 (CVA16) (3)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Vaccinia virus (VACV) (20)
Host species

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Alpaca (23)

Rat (10)

Dog (8)

Rabbit (2)

Mouse (215)

Cat (1)

Human (463)
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Monoclonal (727)
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Unconjugated (727)