All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

Options+

Options

Confirm

Product types

0 selected

Antibodies (727)
Expression system

0 selected

Mammalian Cells (4)

Mammalian (1)
Target

0 selected

CD309/VEGFR-2 (1)

B6R (2)

CXCL10/IP-10 (1)

A33R (2)

CD335/NCR1/NKp46 (1)

gH/gL Complexes (2)

ROBO2 (1)

F8/Coagulation factor VIII (4)

CXCL12/SDF-1 (1)

long-chain α-neurotoxins (1)

GPA33 (1)

IL31 (4)

CD137/4-1BB (2)

GP1 (2)

IFN α2/IFNA2 (1)

M1R (4)

GREM1/DAND2 (1)

Protein P (1)

ROR1/NTRKR1 (1)

RBD (S6P trimer) (3)

CCL3/MIP-1-alpha (1)

S1 N-terminal domain/S1-NTD (3)

CCL11/Eotaxin (1)

TGFB1 (2)

F12/Coagulationfactor XII (1)

G/Major surface glycoprotein G (2)

F/Fusion glycoprotein F0 (16)

L3/CP-H/Protein II (1)

SplB (1)

DPEP3 (1)

Glycoprotein C/Gc (4)

Rabbit hemorrhagic disease virus (RHDV) Capsid protein (1)

E1 & E2 (gp35 & gp70) (3)

IL38/IL1F10 (2)

Neuropeptide Y/NPY (1)

Major surface glycoprotein G (3)

ATTR/Transthyretin amyloidosis (5)

p67 (1)

TGFA/TGF-alpha (1)

ARC (3)

HBEGF (1)

NS1/gp68/gp70 (40)

LRRC15/LIB (1)

CXCL4/PF4 (1)

FSHR (1)

CCL1/I-309 (1)

CXCL13/BCA-1/BLC (1)

CD295/LEPR (1)

ALPP/PLAP (1)

PTHrP/PTHLH(1-34) (1)

Structural polyprotein (1)

L1R/Protein L1 (4)

lukF (1)

G9&A16 complex (2)

GPRC5D (1)

CA9 (1)

CD152/CTLA4 (4)

SERPINE1/PAI-1 (1)

wlaB/pglK (1)

ARG1/Arginase-1 (2)

gB (2)

SNCA/Alpha-synuclein (5)

ADAMTS4 (4)

ADM/Adrenomedullin (1)

SLC39A6/LIV-1 (1)

MSTN/GDF8 (1)

CD254/RANKL/TNFSF11 (1)

CD73/NT5E (2)

botA/BOTOX (1)

RHDV VP60 (1)

CD268/TNFRSF13C (2)

IL18/IL1F4 (1)

PTP4A1/PRL1 (1)

ENT2/SLC29A2 (1)

Capsid protein VP1 (2)

ANGPTL3 (1)

EDB & CD3E (1)

IL17F (1)

HA/Hemagglutinin (2)

Major capsid protein L1 (11)

IL31RA (1)

CD205/LY75/DEC-205 (1)

CD279/PD-1 (9)

IL12B/IL-12 p40 (1)

SOD1 (1)

IL4 (1)

long-chain neurotoxin (1)

RBD (Omicron/KP.2) (2)

APCS/PTX2 (1)

Outer capsid protein VP4 (1)

Beta-toxin Cl13/Cb3 (3)

gH/UL75 (1)

gp120/Glycoprotein 120 (1)

UL130 (1)

GDF15/MIC1 (1)

Prefusion Protein (2)

CD120b/TNFR2 (1)

tetX/Tetanus toxin (1)

CXCL11/I-TAC (1)

OSM/Oncostatin-M (1)

KLKB1/KLK3 (1)

RAGE/AGER (1)

Toxin A/tcdA (2)

gp46 (2)

CD16/FCGR3 (1)

CD122/IL2RB (1)

LTA/TNF-beta (1)

ACE2 (3)

LGR5/GPR49 (1)

L2/Minor capsid protein L2 (2)

Spike glycoprotein E1 (2)

CTGF/CCN2 (1)

AFP/Alpha-fetoprotein (1)

MSLN/Mesothelin (1)

E6/Protein E6 (1)

CXCL1/NAP-3/GRO-alpha (1)

E2s (2)

CCL2/MCP-1 (1)

Virionprotein 1/2/3 (1)

G/Glycoprotein (5)

IL10 (1)

protruding (P) domain (1)

IFNG/IFN-gamma (2)

Gn (9)

CCL14/NCC-2 (1)

Spike (5)

Capsid protein VP25 (2)

IL22 (1)

STEAP1 (1)

p21/Mature core protein (1)

CD48 (1)

BLLF1/MA/GP350 (1)

NLRP3 (1)

gp140/Env Trimer (2)

CD226/DNAM-1 (1)

Tityustoxin VII/Toxin VII/Ts7 (1)

A35R (5)

SSTR2/SRIF-1 (1)

S/Spike glycoprotein (2)

CD84 (1)

CSF1/M-CSF (1)

CD37/TSPAN26 (2)

GDF11/BMP11 (1)

Hemagglutinin/HA (1)

CD62L/SELL (1)

BAG3 (1)

RSPO3 (1)

Alpha-cobratoxin (1)

Outer capsid glycoprotein VP7 (1)

shiga toxin type 2A/stx2A (1)

CSF2/GM-CSF (1)

OPN/SPP1 (1)

IGF1 (1)

ProteinUL128 & UL131A (1)

Procapsid [(VP0/1/3) 5] 12 (2)

PTP4A3/PRL3 (1)

Fusion glycoprotein F0 (5)

IL8/CXCL8 (1)

DKK1 (2)

IL9 (1)

FOLH1/PSMA (1)

RBP2b (1)

GPC (18)

HSV- gB (1)

IL11RA (1)

ADAMTS5 (2)

IL13 (1)

SFRP1 (1)

FGF21 (1)

Virionprotein 1/VP1 (1)

iga/IgA1 protease (1)

CXCL9/MIG (1)

botA/BoNT (2)

CD283/TLR3 (2)

VTCN1/B7-H4 (1)

gp32/gp35/Envelope glycoprotein E1 (1)

Hemagglutinin (H7 subtype) (4)

ROBO4 (1)

CD124/IL4RA (1)

PDGFC (1)

Capsid protein (13)

THPO/Thrombopoietin (1)

TNFa/TNF-alpha (1)

H3L/Ag35 (2)

TSLP (1)

VWF (1)

L1/Major capsid protein L1 (2)

IFNAR1 (1)

gE/Envelope glycoprotein E (1)

IGF2 (1)

Fusion glycoprotein/F Trimer (1)

CD307e/FCRL5 (1)

CD100/SEMA4D (3)

shiga toxin type 2/stx2B (1)

ANGPTL4 (5)

GP/Glycoprotein (5)

NS1/Non-structural protein 1 (1)

Capsid protein VP2 (2)

sLea/CA19-9 (1)

CD127/IL7R (1)

E8L (2)

C1S (1)

TNFSF15/TL1A (1)

CFD (1)

A27L (5)

FedF (1)

P domain (4)

TSG101 (2)

short-chain neurotoxin (1)

NGF/Beta-NGF (2)

Neuraminidase/NA (4)

Protein prM/prM (3)

entB/SEB (1)

IL23A (1)

ssRNA & Genome polyprotein (2)

CD40/TNFRSF5 (1)

gp120 (2)

EDE1 (1)

IL21 (1)

CCL8/MCP-2 (1)

EGFL7 (1)

env/Envelope protein (1)

Glycoprotein G (17)

Fc Block (1)

HGF (1)

Spike glycoprotein 2 (5)

CDH11 (1)

IL17C (1)

Galectin-3/Gal-3 (1)

Heparanase (1)

TREML1/TLT1 (1)

CD228/MELTF (1)

CSF3/G-CSF (1)

SAA (1)

BMP6 (1)

Envelope protein E (13)

F2/Prothrombin/PIVKA-II (1)

stxB/SLT-1b/VT1 (2)

PSCA (1)

CLDN3/Claudin-3 (1)

CD274/PD-L1 (2)

GFRAL (1)

pfo/Perfringolysin O/Theta-toxin (3)

FAP/FAPalpha (1)

gH/BXLF2 (2)

BMP2 (2)

Fusion Protein (1)

CD21/CR2 (1)

Toxin B/tcdB (2)

IL20 (1)

IL1B/IL1F2 (1)

CD319/SLAMF7 (1)

CCL17/TARC (1)

CDH1/CDH11 (1)

APP/Amyloid beta (1)

RBD (Omicron/JN.1) (2)

MERS-CoV RBD (1)

IL2 (1)

CD172a/SIRPA (3)

Dupilumab (2)

IL36RN/IL-1F5/IL-36Ra (1)

GP/Envelopment polyprotein (1)

Spike glycoprotein E2 (1)

TNFSF9/4-1BBL (2)

WNT2 (4)

F/fusion protein (2)

RBD (23)

IL5 (1)

BMP4 (1)

Envelopeglycoprotein E2/gp55 (2)

MUC5AC (1)

CD96 (2)

BMP10 (1)

TREM1 & CD46 (1)

STAT3 (1)

LAMP5 (2)

MUC16/CA-125 (1)

CD227/MUC1 (1)

Alpha-toxin/hly (3)

Envelope glycoprotein GP350 (1)

CD132/IL2RG (1)

CD3 (1)

PRLR (1)

H3L (2)

Flt3 ligand/FLT3LG (1)

HHRF3/US28 (1)

TSHR/LGR3 (2)

IL11 (1)

D8L (2)

Ly6g/Ly-6G.1 (2)

GDF2/BMP9 (1)

Intermediate capsid protein VP6 (1)

CD222/IGF2R (1)

FCGRT/FCRN (1)

shiga toxin type 1B/stx1B (2)

BDNF (1)

gB/BALF4 (2)

CD8a/Lyt2 (3)

IFNA1/Interferon alpha-D (1)

Hepacivirin/NS3P/Viroporin p70 (3)

GP1 glycoprotein (2)

EGFRvIII-specific/EGFR variant III (2)

IL6 (1)

PDGFD (1)

CD52 (1)

CDH17/Cadherin-17 (1)

CCL24/Eotaxin-2/MPIF-2 (1)

DT/Diphtheria toxin (3)

IL1A/IL1F1 (1)

S2 Protein (3)

CD16/CD32 (1)

pro-MSTN/GDF8 (1)

E7/Protein E7 (4)

LRP6 (1)

gD/Envelope glycoprotein D (1)

Mature virion in Complex [(VP0/1/3)5]12 (2)

CX3CL1/Fractalkine (1)

CD49d/ITGA4 (1)

GIPR/GIP-R (1)

env/Env polyprotein (4)

ACVRL1/ALK-1 (1)

Spike glycoprotein (1)

Capsid protein VP 1/2/3 (2)

gB/UL27 (1)

NP/Nucleoprotein (3)

CNR1/CB1 (3)

gB/Envelope glycoprotein B (7)

GPC3/Glypican 3 (1)

EPO (1)

env/Envpolyprotein (1)

IFNB1/IFN-beta (1)

PA/pagA/PA-83 (2)

gp125 (1)

mature virion in complex (5)

A29L (2)

APOE (1)

CXCL2/GRO-beta/MIP2-alpha (1)

CD20/MS4A1 (1)

aPC/Activated protein C (3)

Pvs25 (1)

VP1/Coatprotein VP1 (2)

VSIG4/CRIg (1)

Capsid (1)

PDGFB (1)

PODXL (2)

VLP (1)

Glycoprotein (1)

TGFB2/TGF-beta-2 (1)

Pre-F/Fusion glycoprotein F0 (2)

Capsid protein VP3 (1)

CD198/CCR8 (4)

Hemagglutinin (1)

InlB/Internalin B (1)

Genome polyprotein (5)

fimH (1)

CD337/NCR3/NKp30 (1)

gH/Envelope glycoprotein H (1)

CCL5/RANTES (1)

VEGFA (1)

Fusion glycoprotein (3)

IL17A (4)

ERVW-1/HERV-W-Env (1)

E-DII (1)
Species

0 selected

Human papillomavirus 58 (HPV58) (3)

Staphylococcus aureus (3)

Campylobacter jejuni subsp. (1)

Poliovirus type 1 (PV1) (2)

Human immunodeficiency virus 1 (HIV-1) (9)

Human (177)

Human astrovirus-8 (HAtVs) (1)

Human papillomavirus 16 (HPV16) (2)

Rotavirus (RV) (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

Coxsackievirus B1 (CBV1) (3)

Brazilian scorpion (1)

Nipah virus (NiV) (13)

Rotavirus A (RV-A) (3)

Enterovirus 71 (EV71) (4)

Hantaan virus (HTNV) (2)

Cat (1)

Streptococcus pneumoniae (1)

Clostridium botulinum (2)

Porcine circovirus 2 (PCV2) (2)

Human papillomavirus 6 (HPV6) (1)

Zaire ebolavirus (ZEBOV) (6)

Human parvovirus B19 (HPV B19) (3)

E. coli (4)

Puumala virus (PUUV) (2)

Influenza A virus (Flu A) (5)

Human hepatitis A virus (HHAV) (1)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Hepatitis E virus/HEV (1)

Dengue virus type 2 (DENV-2) (8)

Reston ebolavirus (REBOV) (1)

Dengue virus type 1 (DENV-1) (1)

Human herpesvirus 1 (HSV-1/HHV-1) (3)

Clostridioides difficile (2)

Dobrava-Belgrade virus (DOBV) (2)

Orthohantavirus puumalaense (PUUV) (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

Bundibugyo ebolavirus (BDBV) (1)

Human cytomegalovirus (HCMV/HHV-5) (7)

Dengue virus type 3 (DENV-3) (1)

Epstein-Barr virus (EBV/HHV-4) (2)

Machupo virus (MACV) (1)

Seoul virus (SEOV) (2)

Dog (10)

Ebola virus (EBOV) (1)

Hendra virus (HeV) (2)

Human papillomavirus 59 (HPV59) (1)

Hepatitis C Virus (HCV) (9)

Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

Tai Forest ebolavirus (TAFV) (1)

Lassa virus (LASV) (1)

Dengue virus type 4 (DENV-4) (1)

Coxsackievirus A16 (CVA16) (2)

Rabbit (2)

Plasmodium vivax (2)

Andes virus (ANDV) (2)

Chikungunya virus (CHIKV) (1)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Human metapneumovirus (2)

Human metapneumovirus (HMPV) (4)

Human endogenous retroviruses W (HERV-W) (1)

Sudan ebolavirus (SEBOV) (1)

Varicella-zoster virus (VZV/HHV-3) (4)

Monkey (1)

Human respiratory syncytial virus (HRSV) (12)

Mouse (33)

Zika virus (ZIKV) (4)

Rat (1)

Bovine respiratory syncytial virus (BRSV) (2)

Human adenovirus 3 (HAdV-3) (1)

Sin Nombre virus (SNV) (2)

Japanese encephalitis virus (JEV) (1)

Junin mammarenavirus (JUNV) (1)
Applications

0 selected

ICC (3)

DB (3)

in vivo intra-tumoral regulatory T cell depletion (2)

Western blot (1)

IF (22)

NK cell activation (1)

IHC (18)

RIA (1)

IB (1)

Antagonist (1)

BLI (4)

in vivo (2)

Blocking (2)

Cell Isolation (1)

IP (9)

Nneutralization (1)

Cell Depletion (1)

Neutralizatio (1)

Neutralization (706)

in vivo neutrophil depletion (2)

in vivo study (1)

ELISA (621)

in vivo research (1)

in vivo MDSC depletion (2)

in vivo neutralization (5)

FCM (120)

WB (59)

neutralizing (1)

SPR (46)

in vivo protection (1)

FuncS (4)

in vivo CTLA-4 neutralization (2)

in vitro neutralization (1)

in vivo CD8+ T cell depletion (1)
Reactivity

0 selected

O’nyong’nyong virus (ONNV) (1)

Homo sapiens (Human) (1)

HCoV-229E (2)

Pig (1)

Monkey (1)

Clostridium botulinum (1)

Tick-borne encephalitis virus (1)

Chikungunya virus (CHIKV) (4)

Dengue Virus type 1 (DENV-1) (1)

Human papillomavirus 16 (HPV16) (13)

Influenza A virus (H7N1) (1)

SARS-CoV (1)

Mexican scorpion (3)

Foot-and-mouth disease virus (FMDV) (2)

Porcine circovirus 2 (PCV2) (1)

Human cytomegalovirus (HCMV/HHV-5) (1)

Clostridium tetani (1)

HCoV-OC43 (1)

Clostridioides difficile (2)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Human (57)

Coxsackievirus B1 (CVB1) (3)

SARS-CoV-2 (1)

HSV-1 (3)

Hepatitis E virus (2)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Mayaro virus(MAYV) (1)

Human astrovirus-2 (1)

Human astrovirus-8 (HAtVs) (1)

Dengue Virus type 2 (DENV-2) (1)

Influenza A virus (H7N3) (2)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Naja kaouthia (1)

HCoV-NL63 (1)

Lassa virus (LASV) (16)

HSV-2 (3)

Norwalk virus (3)

Dengue virus (1)

Human respiratory syncytial virus (HRSV) (5)

Hendra virus (HeV) (12)

Hepatitis C Virus (HCV) (43)

Influenza A virus H7 subtype (2)

Ross River Virus (RRV) (2)

Dengue Virus type 3 (DENV-3) (1)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Vaccinia virus (VACV) (20)

Hendra virus (1)

Coxsackievirus A16 (CVA16) (3)

Influenza A virus (H7N9) (1)

Japanese encephalitis virus (JEV) (2)

HIV-1 (1)

Zika virus (1)

IgG1b12 (1)

RD114 retrovirus (1)

Nipah virus (NiV) (13)

E. coli (1)

Puumala virus (1)

O'nyong'nyong virus (ONNV) (1)

Dengue Virus type 4 (DENV-4) (1)

Influenza B virus (2)

Human metapneumovirus (HMPV) (1)

Bacteriophage H19B (2)

Clostridium perfringens (3)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Epstein-Barr virus (EBV/HHV-4) (3)

Crimean-Congo hemorrhagic fever virus (2)

Nipah virus (1)

Murine norovirus 1 (MNV) (1)

Sin Nombre Virus (1)

MERS-CoV (2)

Semliki Forest virus (SFV) (1)

Yellow Fever Virus (YFV) (1)

Measles virus (MeV) (2)

Bovine viral diarrhea virus (BVDV) (2)

Venezuelan equine encephalitis virus (VEEV) (1)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Monkeypox virus (MPXV) (12)

Mouse (25)

Vesicular stomatitis Indiana virus (VSIV) (2)

Chikungunya virus (1)

Escherichia coli (1)

Corynephage omega (3)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Zika virus (ZIKV) (1)

Western equine encephalitis virus (WEEV) (1)

Junin mammarenavirus (JUNV) (3)

Human enterovirus 71 (EV71) (3)

Bacillus anthracis (2)

Norwalk virus (NV) (5)

Canine parvovirus (1)

Rabies virus (RABV) (6)

Poliovirus type 1 (PV1) (1)

Influenza A virus (1)

Listeria monocytogenes (1)

Klebsiella pneumoniae (1)

Guertu Virus (GTV) (3)

West Nile virus (WNV) (1)

Monkeypox virus (5)

Rat (5)

Streptococcus equisimilis (1)

Eastern equine encephalitis virus (EEEV) (1)

Ophiophagus hannah (1)

Scorpion (2)

Machupo virus (MACV) (1)

Parainfluenza virus 5 (PIV5) (1)

Staphylococcus aureus (3)

Hepatitis E virus/HEV (3)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Theileria parva (1)

Heartland Virus (HRTV) (1)

HAstV-1 (2)
Host species

0 selected

Cat (1)

Human (463)

Alpaca (23)

Rat (10)

Dog (8)

Rabbit (2)

Mouse (215)
Clonality

0 selected

Monoclonal (727)
Conjugate

0 selected

Unconjugated (727)