All antibodies are for Research Use Only (RUO) and not for diagnostic or therapeutic use.

Neutralizing Antibodies | Virus Blockade mAbs

Q: Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show functional activity (PRNT/pseudovirus), whereas binding antibodies may not block infection.

Q: PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT uses infectious virus (gold standard); pseudovirus enables BSL-2 functional readouts; sVNT screens receptor blocking on plates for fast throughput.

Q: How do I interpret IC50/ID50 values?

Lower IC50/ID50 denotes stronger neutralization under matched conditions; compare across the same assay setup only.

abinScience neutralizing antibodies (NAbs) block viral entry or fusion and are validated by PRNT, pseudovirus, or surrogate receptor–ligand blocking (sVNT), with IC50/ID50 titers reported where applicable. Panels span coronaviruses (e.g., RBD/ACE2 blockers), influenza (HA), RSV (F), and arboviruses (DENV/ZIKV/CHIKV). Products provide epitope/mechanism notes, variant/strain coverage, isotype and Fc options (native/engineered), and lot-specific CoAs. RUO

Why Researchers Choose abinScience

Functional Validation PRNT, pseudovirus, sVNT with IC50/ID50

Mechanism Annotated Receptor/fusion/capsid blocking

Variant Coverage Documented on datasheets

Isotype & Fc Options IgG/IgA, effector-on/off

Lot-Specific QC CoA, storage, handling guidance

Shop by Pathogen

Shop by Mechanism

Selection Guide

Assay Readout & Potency: PRNT/pseudovirus for functional titers (IC50/ID50); sVNT for rapid screening. Compare IC50 across matched assay conditions.
Epitope & Mechanism: Choose receptor-blocking (e.g., RBD–ACE2) vs. fusion blockers (e.g., RSV F); confirm neutralization across relevant variants/strains.
Isotype & Fc: IgG for general use; IgA for mucosal models; select native vs. engineered Fc (effector-on/off) to match your MoA study.
Matrix & Format: Prefer unconjugated for neutralization assays; use labeled versions for ELISA/flow tracking.
Controls: Include binding-only mAbs, isotypes, and positive NAb controls to benchmark assay performance.

Applications

Neutralization potency ranking and MoA studies

Vaccine/convalescent serum research and escape-variant assessment

Assay development: PRNT, pseudovirus, sVNT and competitive ELISAs

Documents & QC

Datasheet with assay type (PRNT/pseudovirus/sVNT), IC50 and acceptance criteria

Variant/strain coverage, epitope notes and cross-reactivity

Lot-specific CoA; storage, stability and reconstitution

FAQs

Neutralizing vs. binding antibodies—what’s the difference?

Neutralizing antibodies block infection (entry/fusion) and show activity in PRNT/pseudovirus assays, while binding antibodies recognize the antigen without necessarily blocking infection.

PRNT vs. pseudovirus vs. sVNT—how should I choose?

PRNT is the classical infectious-virus gold standard; pseudovirus offers BSL-2 functional readouts; sVNT screens receptor blocking on plates. Choose per biosafety, throughput and MoA.

How do I interpret IC50/ID50 values?

Lower IC50/ID50 indicates stronger neutralization under stated conditions; compare only across matched cell lines, MOI, and incubation protocols.

RUO disclaimer

All antibodies are for Research Use Only and not for diagnostic or therapeutic use.

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Antibodies (727)
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Mammalian Cells (4)

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GREM1/DAND2 (1)

gp32/gp35/Envelope glycoprotein E1 (1)

ROR1/NTRKR1 (1)

RBD (S6P trimer) (3)

ROBO4 (1)

PDGFC (1)

Fusion glycoprotein F0 (5)

CD335/NCR1/NKp46 (1)

IL8/CXCL8 (1)

ROBO2 (1)

IL9 (1)

F8/Coagulation factor VIII (4)

GPC (18)

IL31 (4)

ADAMTS5 (2)

IL13 (1)

FGF21 (1)

CXCL9/MIG (1)

ARC (3)

NS1/Non-structural protein 1 (1)

LRRC15/LIB (1)

CD127/IL7R (1)

E8L (2)

S1 N-terminal domain/S1-NTD (3)

F12/Coagulationfactor XII (1)

A27L (5)

CFD (1)

Capsid protein (13)

G/Major surface glycoprotein G (2)

THPO/Thrombopoietin (1)

L3/CP-H/Protein II (1)

SplB (1)

DPEP3 (1)

Glycoprotein C/Gc (4)

H3L/Ag35 (2)

TNFa/TNF-alpha (1)

TSLP (1)

Rabbit hemorrhagic disease virus (RHDV) Capsid protein (1)

L1/Major capsid protein L1 (2)

gE/Envelope glycoprotein E (1)

IGF2 (1)

E1 & E2 (gp35 & gp70) (3)

IL38/IL1F10 (2)

Neuropeptide Y/NPY (1)

Major surface glycoprotein G (3)

CD100/SEMA4D (3)

p67 (1)

SERPINE1/PAI-1 (1)

Glycoprotein G (17)

Fc Block (1)

HGF (1)

wlaB/pglK (1)

ARG1/Arginase-1 (2)

IL17C (1)

CD295/LEPR (1)

NGF/Beta-NGF (2)

ALPP/PLAP (1)

IL23A (1)

ssRNA & Genome polyprotein (2)

GPRC5D (1)

EDE1 (1)

IL21 (1)

CCL8/MCP-2 (1)

CD205/LY75/DEC-205 (1)

CD274/PD-L1 (2)

GFRAL (1)

FAP/FAPalpha (1)

SOD1 (1)

long-chain neurotoxin (1)

gH/BXLF2 (2)

RBD (Omicron/KP.2) (2)

APCS/PTX2 (1)

SNCA/Alpha-synuclein (5)

BMP2 (2)

Fusion Protein (1)

ADM/Adrenomedullin (1)

CD21/CR2 (1)

Heparanase (1)

MSTN/GDF8 (1)

CD254/RANKL/TNFSF11 (1)

CD73/NT5E (2)

CD228/MELTF (1)

botA/BOTOX (1)

RHDV VP60 (1)

CSF3/G-CSF (1)

CD268/TNFRSF13C (2)

PTP4A1/PRL1 (1)

BMP6 (1)

ENT2/SLC29A2 (1)

Capsid protein VP1 (2)

ANGPTL3 (1)

EDB & CD3E (1)

F2/Prothrombin/PIVKA-II (1)

PSCA (1)

HA/Hemagglutinin (2)

IL31RA (1)

KLKB1/KLK3 (1)

Toxin A/tcdA (2)

IL36RN/IL-1F5/IL-36Ra (1)

Spike glycoprotein E2 (1)

Beta-toxin Cl13/Cb3 (3)

gH/UL75 (1)

IL5 (1)

UL130 (1)

Prefusion Protein (2)

IL20 (1)

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CCL17/TARC (1)

tetX/Tetanus toxin (1)

IL2 (1)

Flt3 ligand/FLT3LG (1)

HHRF3/US28 (1)

STEAP1 (1)

TSHR/LGR3 (2)

IL11 (1)

D8L (2)

Ly6g/Ly-6G.1 (2)

GDF2/BMP9 (1)

Intermediate capsid protein VP6 (1)

CD222/IGF2R (1)

BDNF (1)

CD8a/Lyt2 (3)

IFNA1/Interferon alpha-D (1)

AFP/Alpha-fetoprotein (1)

MSLN/Mesothelin (1)

E2s (2)

Envelopeglycoprotein E2/gp55 (2)

CD96 (2)

BMP10 (1)

Virionprotein 1/2/3 (1)

LAMP5 (2)

protruding (P) domain (1)

Gn (9)

Envelope glycoprotein GP350 (1)

CD132/IL2RG (1)

CD3 (1)

Spike (5)

H3L (2)

Capsid protein VP25 (2)

CCL24/Eotaxin-2/MPIF-2 (1)

ProteinUL128 & UL131A (1)

DT/Diphtheria toxin (3)

Procapsid [(VP0/1/3) 5] 12 (2)

IL1A/IL1F1 (1)

NLRP3 (1)

CD16/CD32 (1)

Tityustoxin VII/Toxin VII/Ts7 (1)

E7/Protein E7 (4)

S/Spike glycoprotein (2)

Hepacivirin/NS3P/Viroporin p70 (3)

RSPO3 (1)

IL6 (1)

PDGFD (1)

shiga toxin type 2A/stx2A (1)

gB/Envelope glycoprotein B (7)

CD124/IL4RA (1)

EPO (1)

env/Envpolyprotein (1)

PTP4A3/PRL3 (1)

mature virion in complex (5)

DKK1 (2)

A29L (2)

FOLH1/PSMA (1)

RBP2b (1)

HSV- gB (1)

gD/Envelope glycoprotein D (1)

IL11RA (1)

CX3CL1/Fractalkine (1)

SFRP1 (1)

GIPR/GIP-R (1)

env/Env polyprotein (4)

Virionprotein 1/VP1 (1)

iga/IgA1 protease (1)

ACVRL1/ALK-1 (1)

botA/BoNT (2)

CD283/TLR3 (2)

VTCN1/B7-H4 (1)

Hemagglutinin (H7 subtype) (4)

sLea/CA19-9 (1)

CD198/CCR8 (4)

InlB/Internalin B (1)

C1S (1)

Genome polyprotein (5)

TNFSF15/TL1A (1)

FedF (1)

CCL5/RANTES (1)

VEGFA (1)

IL17A (4)

VWF (1)

IFNAR1 (1)

Fusion glycoprotein/F Trimer (1)

VP1/Coatprotein VP1 (2)

CD307e/FCRL5 (1)

PDGFB (1)

PODXL (2)

shiga toxin type 2/stx2B (1)

ANGPTL4 (5)

GP/Glycoprotein (5)

Glycoprotein (1)

TGFB2/TGF-beta-2 (1)

Capsid protein VP2 (2)

IFN α2/IFNA2 (1)

M1R (4)

Spike glycoprotein 2 (5)

CDH11 (1)

Galectin-3/Gal-3 (1)

P domain (4)

Protein P (1)

TSG101 (2)

short-chain neurotoxin (1)

Neuraminidase/NA (4)

Protein prM/prM (3)

CD309/VEGFR-2 (1)

entB/SEB (1)

B6R (2)

CXCL10/IP-10 (1)

A33R (2)

CD40/TNFRSF5 (1)

gp120 (2)

gH/gL Complexes (2)

CXCL12/SDF-1 (1)

EGFL7 (1)

long-chain α-neurotoxins (1)

GPA33 (1)

env/Envelope protein (1)

CD137/4-1BB (2)

GP1 (2)

ATTR/Transthyretin amyloidosis (5)

TGFA/TGF-alpha (1)

HBEGF (1)

TREML1/TLT1 (1)

NS1/gp68/gp70 (40)

CXCL4/PF4 (1)

FSHR (1)

CCL3/MIP-1-alpha (1)

SAA (1)

CCL11/Eotaxin (1)

TGFB1 (2)

Envelope protein E (13)

F/Fusion glycoprotein F0 (16)

stxB/SLT-1b/VT1 (2)

CLDN3/Claudin-3 (1)

pfo/Perfringolysin O/Theta-toxin (3)

lukF (1)

G9&A16 complex (2)

GP/Envelopment polyprotein (1)

TNFSF9/4-1BBL (2)

WNT2 (4)

CA9 (1)

CD152/CTLA4 (4)

F/fusion protein (2)

RBD (23)

BMP4 (1)

Toxin B/tcdB (2)

CD319/SLAMF7 (1)

gB (2)

CDH1/CDH11 (1)

CCL1/I-309 (1)

APP/Amyloid beta (1)

CXCL13/BCA-1/BLC (1)

RBD (Omicron/JN.1) (2)

MERS-CoV RBD (1)

PTHrP/PTHLH(1-34) (1)

Structural polyprotein (1)

CD172a/SIRPA (3)

Dupilumab (2)

L1R/Protein L1 (4)

FCGRT/FCRN (1)

shiga toxin type 1B/stx1B (2)

IL17F (1)

gB/BALF4 (2)

Major capsid protein L1 (11)

CD279/PD-1 (9)

IL12B/IL-12 p40 (1)

IL4 (1)

MUC5AC (1)

TREM1 & CD46 (1)

ADAMTS4 (4)

STAT3 (1)

MUC16/CA-125 (1)

SLC39A6/LIV-1 (1)

CD227/MUC1 (1)

Alpha-toxin/hly (3)

PRLR (1)

IL18/IL1F4 (1)

CXCL11/I-TAC (1)

OSM/Oncostatin-M (1)

S2 Protein (3)

pro-MSTN/GDF8 (1)

RAGE/AGER (1)

gp46 (2)

CD16/FCGR3 (1)

CD122/IL2RB (1)

LTA/TNF-beta (1)

ACE2 (3)

L2/Minor capsid protein L2 (2)

LGR5/GPR49 (1)

GP1 glycoprotein (2)

Outer capsid protein VP4 (1)

gp120/Glycoprotein 120 (1)

EGFRvIII-specific/EGFR variant III (2)

GDF15/MIC1 (1)

CD120b/TNFR2 (1)

CD52 (1)

CDH17/Cadherin-17 (1)

GPC3/Glypican 3 (1)

CCL14/NCC-2 (1)

IFNB1/IFN-beta (1)

PA/pagA/PA-83 (2)

gp125 (1)

IL22 (1)

APOE (1)

CXCL2/GRO-beta/MIP2-alpha (1)

LRP6 (1)

p21/Mature core protein (1)

CD48 (1)

Mature virion in Complex [(VP0/1/3)5]12 (2)

CD49d/ITGA4 (1)

Spike glycoprotein E1 (2)

CTGF/CCN2 (1)

Spike glycoprotein (1)

E6/Protein E6 (1)

CXCL1/NAP-3/GRO-alpha (1)

Capsid protein VP 1/2/3 (2)

gB/UL27 (1)

CCL2/MCP-1 (1)

NP/Nucleoprotein (3)

CNR1/CB1 (3)

G/Glycoprotein (5)

IL10 (1)

IFNG/IFN-gamma (2)

gH/Envelope glycoprotein H (1)

Alpha-cobratoxin (1)

Outer capsid glycoprotein VP7 (1)

Fusion glycoprotein (3)

CSF2/GM-CSF (1)

ERVW-1/HERV-W-Env (1)

E-DII (1)

CD20/MS4A1 (1)

OPN/SPP1 (1)

IGF1 (1)

aPC/Activated protein C (3)

Pvs25 (1)

VSIG4/CRIg (1)

Capsid (1)

BLLF1/MA/GP350 (1)

gp140/Env Trimer (2)

CD226/DNAM-1 (1)

A35R (5)

VLP (1)

SSTR2/SRIF-1 (1)

CD84 (1)

Pre-F/Fusion glycoprotein F0 (2)

CSF1/M-CSF (1)

Capsid protein VP3 (1)

CD37/TSPAN26 (2)

Hemagglutinin (1)

GDF11/BMP11 (1)

fimH (1)

Hemagglutinin/HA (1)

CD62L/SELL (1)

CD337/NCR3/NKp30 (1)

BAG3 (1)
Species

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Campylobacter jejuni subsp. (1)

Human herpesvirus 1 (HSV-1/HHV-1) (3)

Poliovirus type 1 (PV1) (2)

Human astrovirus-8 (HAtVs) (1)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (3)

Human cytomegalovirus (HCMV/HHV-5) (7)

Enterovirus 71 (EV71) (4)

Brazilian scorpion (1)

Nipah virus (NiV) (13)

Porcine circovirus 2 (PCV2) (2)

Coxsackievirus A16 (CVA16) (2)

Hantaan virus (HTNV) (2)

Cat (1)

Streptococcus pneumoniae (1)

Human papillomavirus 59 (HPV59) (1)

Clostridium botulinum (2)

E. coli (4)

Zaire ebolavirus (ZEBOV) (6)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (22)

Hepatitis E virus/HEV (1)

Puumala virus (PUUV) (2)

Influenza A virus (Flu A) (5)

Varicella-zoster virus (VZV/HHV-3) (4)

Human hepatitis A virus (HHAV) (1)

Mouse (33)

Dengue virus type 2 (DENV-2) (8)

Reston ebolavirus (REBOV) (1)

Dengue virus type 1 (DENV-1) (1)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (5)

Clostridioides difficile (2)

Dobrava-Belgrade virus (DOBV) (2)

Human papillomavirus 58 (HPV58) (3)

Staphylococcus aureus (3)

Orthohantavirus puumalaense (PUUV) (1)

Dengue virus type 3 (DENV-3) (1)

Epstein-Barr virus (EBV/HHV-4) (2)

Bundibugyo ebolavirus (BDBV) (1)

Human papillomavirus 16 (HPV16) (2)

Machupo virus (MACV) (1)

Rotavirus (RV) (1)

Seoul virus (SEOV) (2)

Human immunodeficiency virus 1 (HIV-1) (9)

Human (177)

Dog (10)

Lassa virus (LASV) (1)

Dengue virus type 4 (DENV-4) (1)

Ebola virus (EBOV) (1)

Hendra virus (HeV) (2)

Hepatitis C Virus (HCV) (9)

Suid alphaherpesvirus 1 (SuHV-1/PRV) (2)

Tai Forest ebolavirus (TAFV) (1)

Rotavirus A (RV-A) (3)

Human metapneumovirus (HMPV) (4)

Human endogenous retroviruses W (HERV-W) (1)

Rabbit (2)

Plasmodium vivax (2)

Coxsackievirus B1 (CBV1) (3)

Andes virus (ANDV) (2)

Chikungunya virus (CHIKV) (1)

Human betacoronavirus 2c EMC/2012 (HCoV-EMC) (2)

Human metapneumovirus (2)

Sudan ebolavirus (SEBOV) (1)

Monkey (1)

Human respiratory syncytial virus (HRSV) (12)

Zika virus (ZIKV) (4)

Human parvovirus B19 (HPV B19) (3)

Rat (1)

Bovine respiratory syncytial virus (BRSV) (2)

Human adenovirus 3 (HAdV-3) (1)

Sin Nombre virus (SNV) (2)

Human papillomavirus 6 (HPV6) (1)

Japanese encephalitis virus (JEV) (1)

Junin mammarenavirus (JUNV) (1)
Applications

0 selected

DB (3)

in vivo neutrophil depletion (2)

Western blot (1)

in vivo study (1)

Cell Depletion (1)

Neutralizatio (1)

Neutralization (706)

in vivo research (1)

in vivo MDSC depletion (2)

NK cell activation (1)

ELISA (621)

RIA (1)

IB (1)

Blocking (2)

Antagonist (1)

BLI (4)

FCM (120)

WB (59)

in vivo (2)

SPR (46)

in vivo CTLA-4 neutralization (2)

FuncS (4)

in vivo intra-tumoral regulatory T cell depletion (2)

ICC (3)

IF (22)

in vivo neutralization (5)

in vivo protection (1)

neutralizing (1)

IHC (18)

in vitro neutralization (1)

in vivo CD8+ T cell depletion (1)

Nneutralization (1)

Cell Isolation (1)

IP (9)
Reactivity

0 selected

Nipah virus (NiV) (13)

O'nyong'nyong virus (ONNV) (1)

Homo sapiens (Human) (1)

Zika virus (1)

Pig (1)

Epstein-Barr virus (EBV/HHV-4) (3)

Influenza A virus (H7N1) (1)

SARS-CoV (1)

Crimean-Congo hemorrhagic fever virus (2)

Nipah virus (1)

Monkey (1)

Influenza B virus (2)

Clostridium botulinum (1)

Tick-borne encephalitis virus (1)

Dengue Virus type 1 (DENV-1) (1)

Clostridioides difficile (2)

Semliki Forest virus (SFV) (1)

Mexican scorpion (3)

Porcine circovirus 2 (PCV2) (1)

Human cytomegalovirus (HCMV/HHV-5) (1)

Clostridium tetani (1)

Influenza A virus (H7N3) (2)

SARS-CoV-2 (1)

Mouse (25)

HSV-1 (3)

Hepatitis E virus (2)

Bovine viral diarrhea virus (BVDV) (2)

Venezuelan equine encephalitis virus (VEEV) (1)

severe fever with thrombocytopenia syndrome virus (SFTSV) (8)

Epstein-Barr virus (HHV-4) (Human herpesvirus 4) (1)

Human astrovirus-2 (1)

Monkeypox virus (MPXV) (12)

Human astrovirus-8 (HAtVs) (1)

Dengue Virus type 2 (DENV-2) (1)

Corynephage omega (3)

Severe acute respiratory syndrome coronavirus (SARS-CoV) (1)

Vesicular stomatitis Indiana virus (VSIV) (2)

HSV-2 (3)

Norwalk virus (3)

Western equine encephalitis virus (WEEV) (1)

Junin mammarenavirus (JUNV) (3)

Influenza A virus H7 subtype (2)

Dengue Virus type 3 (DENV-3) (1)

Rabies virus (RABV) (6)

Listeria monocytogenes (1)

Dengue Virus type 4 (DENV-4) (1)

Parainfluenza virus 5 (PIV5) (1)

Influenza A virus (H7N9) (1)

Monkeypox virus (5)

Rat (5)

Japanese encephalitis virus (JEV) (2)

HIV-1 (1)

IgG1b12 (1)

Eastern equine encephalitis virus (EEEV) (1)

Ophiophagus hannah (1)

RD114 retrovirus (1)

Machupo virus (MACV) (1)

E. coli (1)

Puumala virus (1)

Human metapneumovirus (HMPV) (1)

Bacteriophage H19B (2)

Clostridium perfringens (3)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (5)

Yellow Fever Virus (YFV) (1)

Measles virus (MeV) (2)

HCoV-229E (2)

Murine norovirus 1 (MNV) (1)

Sin Nombre Virus (1)

MERS-CoV (2)

O’nyong’nyong virus (ONNV) (1)

Chikungunya virus (CHIKV) (4)

Human papillomavirus 16 (HPV16) (13)

Middle East respiratory syndrome-related coronavirus (MERS-CoV) (8)

Zika virus (ZIKV) (1)

HCoV-OC43 (1)

Human T-cell leukemia virus 1 (HTLV-1) (2)

Human (57)

Coxsackievirus B1 (CVB1) (3)

Chikungunya virus (1)

Foot-and-mouth disease virus (FMDV) (2)

Escherichia coli (1)

Bacillus anthracis (2)

Mayaro virus(MAYV) (1)

Human enterovirus 71 (EV71) (3)

Guertu Virus (GTV) (3)

Naja kaouthia (1)

West Nile virus (WNV) (1)

HCoV-NL63 (1)

Norwalk virus (NV) (5)

Canine parvovirus (1)

Poliovirus type 1 (PV1) (1)

Influenza A virus (1)

Klebsiella pneumoniae (1)

Hendra virus (HeV) (12)

Hepatitis C Virus (HCV) (43)

Ross River Virus (RRV) (2)

Staphylococcus aureus (3)

Streptococcus equisimilis (1)

Lassa virus (LASV) (16)

Scorpion (2)

Dengue virus (1)

Human respiratory syncytial virus (HRSV) (5)

Heartland Virus (HRTV) (1)

HAstV-1 (2)

Hendra virus (1)

Coxsackievirus A16 (CVA16) (3)

Hepatitis E virus/HEV (3)

Human coronavirus HKU1 (HCoV-HKU1) (1)

Vaccinia virus (VACV) (20)

Rabbit hemorrhagic disease virus (RHDV) GI.2 (1)

Theileria parva (1)
Host species

0 selected

Rat (10)

Alpaca (23)

Cat (1)

Mouse (215)

Dog (8)

Rabbit (2)

Human (463)
Clonality

0 selected

Monoclonal (727)
Conjugate

0 selected

Unconjugated (727)