| Catalog No. | HF802026 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1-kappa (DVD-Ig) |
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| Expression system | Mammalian Cells |
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| Species | Human |
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| Clonality | Monoclonal |
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| Target | IL1F1, Interleukin-1 alpha, IL1A, Hematopoietin-1, IL-1 alpha, Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta |
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| Endotoxin level | Please contact with the lab for this information. |
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| Purity | >95% as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P01583 & P01584 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. |
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| Alternate Names | Bispecific, ABT-981, 1791411-57-8 |
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| Background | Goflikicept (RPH 104) is a fusion protein that selectively binds and inactivates both circulating IL-1β and IL-1α. Goflikicept has the potential for the research of ST-segment elevation myocardial infarction (STEMI).
• Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure., PMID:31836429
• Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis., PMID:33200890
• Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance., PMID:33037057
• The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters., PMID:35139823
• Targeting IL-1β in the Treatment of Atherosclerosis., PMID:33362770
• IL-1 family cytokines in cardiovascular disease., PMID:29198612
• Potential of cannabidiol as acne and acne scar treatment: novel insights into molecular pathways of pathophysiological factors., PMID:38904694
• IL1A and IL1B gene polymorphisms and keratoconus susceptibility: evidence from an updated meta-analysis., PMID:33978542
• Association between the IL-1A, IL-1B and IL-1R polymorphisms and lymphoma., PMID:34159887
• Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies., PMID:32825489
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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