| Catalog No. | HC609016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | CD136, Macrophage-stimulating protein receptor, PTK8, MST1R, p185-Ron, RON, CDw136, MSP receptor, Protein-tyrosine kinase 8 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | Q04912 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | IMCRON-8, RON8, 1188275-92-4 |
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| Background | Narnatumab (IMC-RON8) is a neutralizing human monoclonal antibody that blocks RON binding to its ligand, macrophage-stimulating protein (MSP), with a Kd of 32 pM. Narnatumab can be used for the research of cancer.
• Macrophage-stimulating protein and RON receptor tyrosine kinase: potential regulators of macrophage inflammatory activities., PMID:12472665
• Macrophage stimulating protein., PMID:10549357
• MSP-RON Pathway: Potential Regulator of Inflammation and Innate Immunity., PMID:33117355
• An Introduction and Overview of RON Receptor Tyrosine Kinase Signaling., PMID:36833444
• Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase., PMID:12807733
• Roles of macrophage stimulating protein and tyrosine kinase receptor RON in smoke-induced airway inflammation of rats., PMID:26464622
• Kinases involved in MSP/RON signaling., PMID:10080538
• Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility., PMID:9045873
• MSP-RON signalling in cancer: pathogenesis and therapeutic potential., PMID:23792360
• The ron receptor tyrosine kinase: a key regulator of inflammation and cancer progression., PMID:24266348
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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