| Catalog No. | HW342066 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | ACT35 antigen, TXGP1L, TAX transcriptionally-activated glycoprotein 1 receptor, Tumor necrosis factor receptor superfamily member 4, TNFRSF4, OX40L receptor, CD134 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P43489 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | GBR-830, 2126777-87-3 |
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| Background | Ivuxolimab (PF-04518600) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response
• Targeting co-stimulatory molecules in autoimmune disease., PMID:32939077
• OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target., PMID:38236520
• The role of OX40 ligand/OX40 axis signalling in atopic dermatitis., PMID:38836560
• Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists., PMID:39636970
• An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis., PMID:38607026
• Entry of betaherpesviruses., PMID:31439151
• OX40 (CD134) and OX40L., PMID:19760068
• Research progress in OX40/OX40L in allergic diseases., PMID:39404736
• The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8+ T-cell immunity., PMID:37932534
• The role of tumor necrosis factor receptor superfamily member 4 (TNFRSF4) gene expression in diagnosis and prognosis of acute myeloid leukemia., PMID:34453673
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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