| Catalog No. | HY546026 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1-Kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Meconium antigen 100, CEACAM5, CEA, CD66e, Carcinoembryonic antigen-related cell adhesion molecule 5, Carcinoembryonic antigen |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P06731 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | CEA-IL-2v, RG7813, RO-6895882, 1509916-03-3 |
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| Background | HY-P990940 is an CEACAM5-targeting IgG1κ type human antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
• Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) in cancer progression and metastasis., PMID:23903773
• Platelet Carcinoembryonic Antigen Cell Adhesion Molecule 5 (CEACAM5) as a Possible Novel Diagnostic Tool for Evaluation of Acute Coronary Syndrome., PMID:31865362
• Carcinoembryonic Antigen-Related Cell Adhesion Molecule Type 5 Receptor-Targeted Fluorescent Intraoperative Molecular Imaging Tracer for Lung Cancer: A Nonrandomized Controlled Trial., PMID:36705924
• CEACAM5 stimulates the progression of non-small-cell lung cancer by promoting cell proliferation and migration., PMID:32993395
• A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo., PMID:34740610
• CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial-mesenchymal transition via inhibiting MDM2., PMID:36377775
• Specific Binding to Differentially Expressed Human Carcinoembryonic Antigen-Related Cell Adhesion Molecules Determines the Outcome of Neisseria gonorrhoeae Infections along the Female Reproductive Tract., PMID:29760215
• Trajectories of Perioperative Serum Tumor Markers and Colorectal Cancer Outcomes: A Retrospective, Multicenter Longitudinal Cohort Study., PMID:34801967
• Detection and clinical significance of CEACAM5 methylation in colorectal cancer patients., PMID:37942534
• CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling., PMID:17653079
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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