| Catalog No. | HY321016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1-lambda |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | ICAM1, Major group rhinovirus receptor, CD54, ICAM-1, Intercellular adhesion molecule 1 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P05362 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | BI-505, 1987854-08-9 |
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| Background | Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects.
• Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation., PMID:39317271
• Quercetin inhibits TNF-α induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro., PMID:32957369
• ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer., PMID:34381029
• The Roles of Lipoprotein in Psoriasis., PMID:32013194
• Islet beta-cells and intercellular adhesion molecule-1 (ICAM-1): Integrating immune responses that influence autoimmunity and graft rejection., PMID:37619906
• Genetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States., PMID:37062471
• Systematic pan-cancer analysis insights into ICAM1 as an immunological and prognostic biomarker., PMID:38979944
• Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis., PMID:35220887
• Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions., PMID:34715236
• Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane., PMID:38924997
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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