| Catalog No. | HY195016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Mouse |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | T200, Leukocyte common antigen, CD45, L-CA, Receptor-type tyrosine-protein phosphatase C, PTPRC |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P08575 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Background | Apamistamab is a monoclonal antibody developed for targeted radiotherapy in hematologic malignancies. It is commonly used in radioimmunotherapy as a carrier for radioactive isotopes, facilitating the targeted destruction of malignant cells while minimizing damage to healthy tissues. It has been studied primarily in the context of conditioning regimens for hematopoietic stem cell transplantation, particularly in treating relapsed or refractory leukemias and lymphomas.
• Protein tyrosine phosphatase receptor type C (PTPRC or CD45)., PMID:34039664
• Immune receptor inhibition through enforced phosphatase recruitment., PMID:33087934
• Orientation-dependent CD45 inhibition with viral and engineered ligands., PMID:39454026
• Innate immune remodeling by short-term intensive fasting., PMID:34705313
• CD45-negative follicular lymphoma., PMID:32163561
• Dynamics of Cell Generation and Turnover in the Human Heart., PMID:26073943
• The Roseoloviruses Downregulate the Protein Tyrosine Phosphatase PTPRC (CD45)., PMID:33952641
• CD45-PET is a robust, non-invasive tool for imaging inflammation., PMID:39843738
• Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing., PMID:28262555
• The Protein Tyrosine Phosphatase SHP-1 (PTPN6) but Not CD45 (PTPRC) Is Essential for the Ligand-Mediated Regulation of CD22 in BCR-Ligated B Cells., PMID:33990399
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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