| Catalog No. | HB011066 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Sialic acid-binding Ig-like lectin 2, Siglec-2, CD22, T-cell surface antigen Leu-14, BL-CAM, SIGLEC2, B-lymphocyte cell adhesion molecule, B-cell receptor CD22 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P20273 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | ACD22-VCMMAE, DCDT2980S, FCU2803, RG-7593, RO5541072-000 |
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| Background | HY-P990930 is an CD22-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
• Targeting Human CD22/Siglec-2 with Dimeric Sialosides as Novel Oligosaccharide Mimetics., PMID:35881556
• Siglec-1 and -2 as potential biomarkers in autoimmune disease., PMID:26752092
• Siglecs in Brain Function and Neurological Disorders., PMID:31546700
• Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes., PMID:9636173
• Down-regulation of siglec-2 (CD22) predicts worse overall survival from HBV-related early-stage hepatocellular carcinoma: a preliminary analysis from Gene Expression Omnibus., PMID:30355653
• Versatile biosynthetic engineering of sialic acid in living cells using synthetic sialic acid analogues., PMID:11751912
• Characterisation of the Dynamic Interactions between Complex N-Glycans and Human CD22., PMID:31095840
• Loss of N-glycolylneuraminic acid in human evolution. Implications for sialic acid recognition by siglecs., PMID:10722703
• Insights into the transcriptional regulation of CD22 in B cell chronic lymphocytic leukemia., PMID:40054694
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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