| Catalog No. | HB754026 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Emfilermin, D factor, HILDA, LIF, MLPLI, Melanoma-derived LPL inhibitor, Leukemia inhibitory factor, Differentiation-stimulating factor |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P15018 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 2740565-02-8 |
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| Background | Falbikitug is a humanized immunoglobulin G1-kappa, anti-LIF monoclonal antibody. Falbikitug is an antineoplastic.
• Leukemia inhibitory factor (LIF)., PMID:26187859
• Biomolecular Markers of Recurrent Implantation Failure-A Review., PMID:34576245
• Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring., PMID:30996350
• Augmentative effects of leukemia inhibitory factor reveal a critical role for TYK2 signaling in vascular calcification., PMID:39084258
• Nephron induction., PMID:12386301
• p53 and reproduction., PMID:29307398
• A peptide derived from the CD loop-D helix region of ciliary neurotrophic factor (CNTF) induces neuronal differentiation and survival by binding to the leukemia inhibitory factor (LIF) receptor and common cytokine receptor chain gp130., PMID:22000729
• Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment., PMID:36441800
• TGF-β-driven LIF expression influences neutrophil extracellular traps (NETs) and contributes to peritoneal metastasis in gastric cancer., PMID:38490994
• Super-Enhancer Driven LIF/LIFR-STAT3-SOX2 Regulatory Feedback Loop Promotes Cancer Stemness in Head and Neck Squamous Cell Carcinoma., PMID:39206755
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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