| Catalog No. | HF621016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG4 |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | F2, Coagulation factor II, Prothrombin |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P00734 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | JNJ9375, JNJ-375, JNJ-64179375 |
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| Background | Ichorcumab (JNJ-375) is a fully human IgG4 antibody that targets Thrombin. Ichorcumab binds to exosite 1 on thrombin and inhibits substrate binding but not catalytic activity. The isotype control for Ichorcumab can refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).
• Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus., PMID:21239755
• Associations of coagulation factor V Leiden and prothrombin G20210A mutations with Budd-Chiari syndrome and portal vein thrombosis: a systematic review and meta-analysis., PMID:24793031
• Prothrombin G20210A, factor V Leiden, and factor XIII Val34Leu: common mutations of blood coagulation factors and deep vein thrombosis in Austria., PMID:10904101
• Molecular basis of rare congenital bleeding disorders., PMID:36369145
• Risk of cardiovascular disease in double heterozygous carriers and homozygous carriers of F5 R506Q (factor V Leiden) and F2 (prothrombin) G20210A: a retrospective family cohort study., PMID:21275962
• Exploring causal correlations between plasma proteins and peripheral neuropathy: a Mendelian randomization., PMID:39268072
• First-Trimester Preeclampsia-Induced Disturbance in Maternal Blood Serum Proteome: A Pilot Study., PMID:39408980
• Aestivation induces changes in transcription and translation of coagulation factor II and fibrinogen gamma chain in the liver of the African lungfish Protopterus annectens., PMID:26449974
• Brisk Walking Pace Offsets Venous Thromboembolism Risk Equivalent to Established Monogenic Mutations., PMID:39500367
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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