| Catalog No. | HX881036 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| Host species | Human |
|---|
| Isotype | IgG1-kappa |
|---|
| Expression system | Mammalian Cells |
|---|
| Clonality | Monoclonal |
|---|
| Target | K-cadherin, CDH6, Cadherin-6, Kidney cadherin |
|---|
| Endotoxin level | Please contact the lab for this information. |
|---|
| Purity | >95% purity as determined by SDS-PAGE. |
|---|
| Purification | Protein A/G purified from cell culture supernatant. |
|---|
| Accession | P55285 |
|---|
| Form | Liquid |
|---|
| Storage buffer | 0.01M PBS, pH 7.4. |
|---|
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
|---|
| Alternate Names | 2610074-56-9 |
|---|
| Background | Raludotatug is a humanized immunoglobulin G1-kappa, anti-CDH6 monoclonal antibody. Raludotatug is an antineoplastic.
• Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models., PMID:38205802
• Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers., PMID:28526733
• Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface., PMID:27563818
• Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity., PMID:32600462
• Alterations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma., PMID:10940709
• Mesothelin promotes the migration of endometrioid carcinoma and is associated with the MELF pattern., PMID:39182448
• The GLI2/CDH6 axis enhances migration, invasion and mitochondrial fission of stomach adenocarcinoma cells., PMID:37523816
• Cadherin 6 promotes neural crest cell detachment via F-actin regulation and influences active Rho distribution during epithelial-to-mesenchymal transition., PMID:24917505
• Kidney development in cadherin-6 mutants: delayed mesenchyme-to-epithelial conversion and loss of nephrons., PMID:10864459
• Cadherin 6 is a new RUNX2 target in TGF-β signalling pathway., PMID:24069422
|
|---|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
|---|
