| Catalog No. | HB709046 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG1-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO, AXL |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P30530 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | BA301, 2460400-28-4 |
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| Background | Mecbotamab is a humanized IgG1-κ antibody targeting to AXL receptor tyrosine kinase (AXL). Mecbotamab can serves as a conditionally active biologic (CAB), which can be conjugated with MMAE (HY-15162) via a cleavable linker, to form ADC Mecbotamab vedotin (BA3011).
• Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site., PMID:9178760
• Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias., PMID:9130617
• Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors., PMID:36630517
• The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer., PMID:25568918
• Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia., PMID:39395205
• Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain., PMID:8108112
• Serum AXL is a potential molecular marker for predicting COVID-19 progression., PMID:38799467
• Clinical significance of AXL kinase family in gastric cancer., PMID:12168903
• Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells., PMID:21730355
• The genomic structure of the human UFO receptor., PMID:8381225
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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