| Catalog No. | HY550026 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Humanized |
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| Isotype | IgG4-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | Vimentin, VIM |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P08670 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | hzVSF-v13, hzVSF_var13, HzVSF-13, 2460809-80-5 |
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| Background | Burfiralimab (hzVSF-v13) is a monoclonal IgG4 antibody against vimentin expressed on the surface of virus-infected cells, with broad-spectrum antiviral activity and anti-inflammatory effects against virus-induced inflammation. Burfiralimab can be used in severe COVID-19 studies.
• Roles of vimentin in health and disease., PMID:35487686
• Spatial single-cell protein landscape reveals vimentinhigh macrophages as immune-suppressive in the microenvironment of hepatocellular carcinoma., PMID:39327501
• Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-β receptor 1 recycling by stabilizing vimentin., PMID:37641404
• FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression., PMID:37915048
• Vimentin Inhibits Dengue Virus Type 2 Invasion of the Blood-Brain Barrier., PMID:35433510
• Vimentin on the move: new developments in cell migration., PMID:30505430
• Vimentin, inversely correlating with infiltration of CD8 + T lymphocytes, promotes nuclear translocation of PD-L1 in esophageal squamous cell carcinoma., PMID:38901494
• Vimentin as a universal receptor for pseudorabies virus infection in pig and human cells., PMID:39549807
• PROTAC-mediated vimentin degradation promotes terminal erythroid differentiation of pluripotent stem cells., PMID:39294765
• Vimentin, colon cancer progression and resistance to butyrate and other HDACis., PMID:27072512
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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