| Catalog No. | HV263016 |
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| Species reactivity | Human |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG2-kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | IL17R, CDw217, IL-17RA, Interleukin-17 receptor A, IL-17 receptor A, IL17RA, CD217 |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | Q96F46 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | AMG827, KHK4827, 1174395-19-7 |
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| Background | Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis.
• From Messengers to Receptors in Psoriasis: The Role of IL-17RA in Disease and Treatment., PMID:34201664
• Evaluation of interleukin-17 receptor (IL-17RA) gene expression in PBMCs of patients with premature coronary artery disease., PMID:35913009
• Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling., PMID:38470486
• Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer., PMID:37686343
• Role and functional mechanisms of IL‑17/IL‑17R signaling in pancreatic cancer (Review)., PMID:39219271
• Loss of Interleukin-17RA Expression is Associated with Tumour Progression in Colorectal Carcinoma., PMID:32462420
• Associations of IL-17 and IL-17 receptor polymorphisms with Behçet's disease in Denizli Province of Turkey., PMID:36701075
• Increased chemokine receptor IL-17RA expression is associated with poor survival in gastric cancer patients., PMID:26261590
• Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop., PMID:32696476
• Characteristic Pattern of IL-17RA, IL-17RB, and IL-17RC in Monocytes/Macrophages and Mast Cells From Patients With Bullous Pemphigoid., PMID:31572359
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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