| Catalog No. | HX243016 |
|---|
| Species reactivity | Human |
|---|
| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
|---|
| Host species | Humanized |
|---|
| Isotype | IgG1-kappa |
|---|
| Expression system | Mammalian Cells |
|---|
| Clonality | Monoclonal |
|---|
| Target | IL-5R subunit alpha, IL-5 receptor subunit alpha, IL5RA, IL-5RA, IL-5R-alpha, Interleukin-5 receptor subunit alpha, CDw125, CD125, IL5R |
|---|
| Endotoxin level | Please contact the lab for this information. |
|---|
| Purity | >95% purity as determined by SDS-PAGE. |
|---|
| Purification | Protein A/G purified from cell culture supernatant. |
|---|
| Accession | Q01344 |
|---|
| Form | Liquid |
|---|
| Storage buffer | 0.01M PBS, pH 7.4. |
|---|
| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
|---|
| Alternate Names | BIW-8405, KHK4563, MEDI-563, 1044511-01-4 |
|---|
| Background | Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma.
• Benralizumab for the treatment of asthma., PMID:29517082
• Eosinophils, the IL-5/IL-5Rα axis, and the biologic effects of benralizumab in severe asthma., PMID:31734469
• Serum Concentration of IL-5 Receptor (IL-5R) and Associations with Disease Severity in Patients with Chronic Spontaneous Urticaria (CSU) and Atopic Dermatitis (AD)., PMID:39062845
• A genetic effect of IL-5 receptor α polymorphism in patients with aspirin-exacerbated respiratory disease., PMID:23470716
• IL-5 and IL-5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans., PMID:17620072
• Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output., PMID:19654410
• IL-3 Maintains Activation of the p90S6K/RPS6 Pathway and Increases Translation in Human Eosinophils., PMID:26276876
• Cord blood molecular biomarkers of eosinophilopoiesis: kinetic analysis of GATA-1, MBP1 and IL-5R alpha mRNA expression., PMID:20337967
|
|---|
| Note | For research use only. Not suitable for clinical or therapeutic use. |
|---|
