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Research Grade Aflibercept (HB941296)

Price(USD): $
Spec:
  • 100ug
  • 1mg
Number:
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  • Datasheet
Overview
Catalog No.HB941296
Species reactivityHuman
ApplicationsELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host speciesHuman
IsotypeIgG1-Fc
Expression systemMammalian Cells
ClonalityMonoclonal
TargetVascular endothelial growth factor A, VPF, VEGFA, VEGF, Vascular permeability factor, VEGF-A
Endotoxin levelPlease contact the lab for this information.
Purity>95% purity as determined by SDS-PAGE.
PurificationProtein A/G purified from cell culture supernatant.
AccessionP15692
FormLiquid
Storage buffer0.01M PBS, pH 7.4.
Stability and StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Alternate Names862111-32-8
BackgroundSuvemcitug is a humanized IgG1κ antibody targeting VEGF derived from the African hare (Oryctolagus cuniculus).
• Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy., PMID:12409337
• Vascular endothelial growth factor and its receptors., PMID:7515293
• Tumors: wounds that do not heal-redux., PMID:25568067
• Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis., PMID:12461084
• Differential expression of vascular endothelial growth factor (vascular permeability factor) forms in rat tissues., PMID:8527159
• Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin., PMID:9036922
• Synthesis, storage, and release of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) by human mast cells: implications for the biological significance of VEGF206., PMID:9529385
• Effects of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF) on haemodynamics and permselectivity of the isolated perfused rat kidney., PMID:9568844
• Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis., PMID:21411713
• Isolation and purification of vascular endothelial growth factor (VEGF) from ascitic fluid of ovarian cancer patients., PMID:15188027
NoteFor research use only. Not suitable for clinical or therapeutic use.
Images
  • SEC-HPLC

    SEC-HPLC detection for Research Grade Aflibercept.

  • Bioactivity

    Detects Human VEGFA in indirect ELISAs.

  • SDS-PAGE

    SDS-PAGE for Research Grade Aflibercept.

  • Flow CytoMetry

    Flow-cytometry using FITC anti-human VEGFA antibody. U87 cells were fixed and permeabilized, then stained with an irrelevant antibody (Blue Histogram) or an FITC anti-human VEGFA monoclonal antibody (Catalog: HB941296, Yellow Histogram) at a concentration of 5 µg/ml for 30 mins at RT. After washing, cells analysed on a NovoCyte Flow Cytometer.

References

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