| Catalog No. | HW328296 |
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| Species reactivity | Human |
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| Applications | ELISA, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | Fusion-[GCG (glucagon) 98-127 (glucagon-like peptide 1, GLP1) 7-36]2-IgG4-Fc (Fragment constant) |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | GLP-1 receptor, Glucagon-like peptide 1 receptor, GLP1R, GLP-1-R, GLP-1R |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P43220 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | 923950-08-7 |
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| Background | Liraglutide, 97% similar to native human GLP-1, differs primarily by substituting arginine for lysine at position 34 and involves attaching a C-16 fatty acid (palmitic acid) with a glutamic acid spacer at the remaining lysine residue at position 26.
• The physiology of glucagon-like peptide 1., PMID:17928588
• Glucagon-like peptide-1 receptor: mechanisms and advances in therapy., PMID:39289339
• The structure and function of the glucagon-like peptide-1 receptor and its ligands., PMID:21950636
• Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist., PMID:33177239
• Glucagon-like peptide-1 receptor., PMID:39626623
• Prognostic impact of glucagon-like peptide-1 receptor (GLP1R) expression on cancer survival and its implications for GLP-1R agonist therapy: an integrative analysis across multiple tumor types., PMID:39777709
• Safety issues with glucagon-like peptide-1 receptor agonists (pancreatitis, pancreatic cancer and cholelithiasis): Data from randomized controlled trials., PMID:28244632
• Glucagon-like-peptide 1 receptor agonism and attempted suicide: A Mendelian randomisation study to assess a potential causal association., PMID:38778795
• Glucagon-Like Peptide-1 Receptor Agonism and Suicide Risk: Evidence From Mendelian Randomization., PMID:38879463
• GLP-1, GIP/GLP-1, and GCGR/GLP-1 receptor agonists: Novel therapeutic agents for metabolic dysfunction-associated steatohepatitis., PMID:39735270
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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