| Catalog No. | VK515056 |
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| Description | Lesofavumab is a recombinant monoclonal antibody to Influenza B virus hemagglutinin. Lesofavumab is a human monoclonal antibody that can be potentially used in the treatment of Influenza B infection. Genentech, a subsidiary of Roche, is developing Lesofavumab (RG6024), a monoclonal antibody, for the treatment of influenza B infections. |
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| Species reactivity | Influenza B virus |
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| Applications | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
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| Host species | Human |
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| Isotype | IgG1, kappa |
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| Expression system | Mammalian Cells |
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| Clonality | Monoclonal |
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| Target | HA/Hemagglutinin |
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| Endotoxin level | Please contact the lab for this information. |
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| Purity | >95% purity as determined by SDS-PAGE. |
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| Purification | Protein A/G purified from cell culture supernatant. |
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| Accession | P03461 |
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| Form | Liquid |
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| Storage buffer | 0.01M PBS, pH 7.4. |
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| Stability and Storage | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C. |
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| Alternate Names | RG6024, RG6024, MHAB5553A, RG70026, RO7045557, 1807960-57-1 |
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| Background | Lesofavumab (MHAB5553A) is a human IgG1κ anti-influenza B virus antibody.
• SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity., PMID:31913745
• KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity., PMID:35266843
• Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression., PMID:35253629
• Streptococcus pneumoniae extracellular vesicles aggravate alveolar epithelial barrier disruption via autophagic degradation of OCLN (occludin)., PMID:38497494
• Engineered Macrophage Membrane-Coated S100A9-siRNA for Ameliorating Myocardial Ischemia-Reperfusion Injury., PMID:39264262
• Phosphorylation of ATG18a by BAK1 suppresses autophagy and attenuates plant resistance against necrotrophic pathogens., PMID:32804012
• TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1., PMID:38009729
• A/(H1N1) pdm09 NS1 promotes viral replication by enhancing autophagy through hijacking the IAV negative regulatory factor LRPPRC., PMID:36300799
• Protein disulfide isomerases (PDIs) negatively regulate ebolavirus structural glycoprotein expression in the endoplasmic reticulum (ER) via the autophagy-lysosomal pathway., PMID:35130104
• Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress., PMID:36719671
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| Note | For research use only. Not suitable for clinical or therapeutic use. |
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