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Anti-Measles virus/MeV F/Fusion Antibody (mAb 77)
Overview
Catalog No. VK446023
Host species Mouse
Species reactivity Measles virus (MeV)
Form Liquid
Storage buffer 0.01M PBS, pH 7.4.
Purity >90% as determined by SDS-PAGE.
Clonality Monoclonal
Isotype IgG2a, kappa
Applications Neutralization, in vivo
Target F/fusion protein
Purification Protein A/G purified from cell culture supernatant.
Endotoxin level Please contact with the lab for this information.
Accession P69353
Stability and Storage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative nameFusion glycoprotein F0, Fusion glycoprotein F2, Fusion glycoprotein F1, F
Clone IDmAb 77
Note For research use only.
Description

mAb 77 effectively neutralizes MeV infection in vitro and significantly reduces viral replication and loads in vivo in the cotton rat model. Mechanistic assays revealed that mAb 77 prevents the completion of membrane fusion, but does so without inhibiting F protein activation, fusion initiation, or the formation of the extended intermediate.